Phosphoric Acid

Phosphoric Acid

SCHEMBL8777433

COc1cc(Nc2ccccc2)ccc1[N+]#N.O=P([O-])(O)O

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
PPARG P37231 1/20 0.40
PPARD Q03181 1/20 0.40
PPARA Q07869 1/20 0.40
MTNR1B P49286 4/20 0.39
MTNR1A P48039 2/20 0.39
SNCA P37840 1/20 0.39
MAPK8 P45983 2/20 0.38
MAPK9 P45984 1/20 0.38
MAPK10 P53779 1/20 0.38
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CCNT1 O60563 1/20 0.37
CDK9 P50750 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL92096 0.89 MEN1 (0.47) MEN1KMT2ACASP3SENP8SENP7
Hydrochloric Acid SCHEMBL8080600 0.88 MEN1 (0.46) MEN1KMT2ACASP3SENP8SENP7
Bromide SCHEMBL9172630 0.88 MEN1 (0.46) MEN1KMT2ACASP3SENP8SENP7
Sulfuric Acid SCHEMBL5698877 0.87 MEN1 (0.45) MEN1KMT2ACASP3SENP8SENP7
Sulfuric Acid SCHEMBL1123017 0.87 PPARG (0.44) MEN1KMT2ACASP3SENP8SENP7
Sulfuric Acid SCHEMBL6357625 0.87 MEN1 (0.47) MEN1KMT2ACASP3SENP8SENP7
Hydrochloric Acid SCHEMBL11066823 0.86 MEN1 (0.45) MEN1KMT2ACASP3SENP8SENP7
Sulfuric Acid SCHEMBL6929881 0.86 PPARG (0.43) MEN1KMT2ACASP3SENP8SENP7
SCHEMBL27805679 0.84 MEN1 (0.43) MEN1KMT2ACASP3SENP8SENP7
2-Methoxyethanol SCHEMBL11874819 0.84 MEN1 (0.44) MEN1KMT2ACASP3SENP8SENP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0811878-A1 A diazo based imaging element having increased sensitivity AGFA-GEVAERT N.V. (BE) 1997-12-10 EP disclosed