Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TOP1 | P11387 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661171 | 0.85 | TOP1 (0.57) | TOP1TOP2ATOP2BPTGS1 | |
| SCHEMBL11802443 | 0.84 | HPGD (0.59) | MAPK1TOP1TOP2ATOP2B | |
| SCHEMBL8844428 | 0.83 | NPC1 (0.65) | MAPK1TOP1TOP2ATOP2B | |
| SCHEMBL9417251 | 0.82 | MEN1 (0.60) | — | |
| SCHEMBL8778033 | 0.80 | HDAC1 (0.50) | HDAC1HDAC2HDAC3MAPK1HDAC4 | |
| SCHEMBL5223727 | 0.79 | PTGS1 (0.72) | HDAC1HDAC2HDAC3MAPK1PTGS1 | |
| SCHEMBL9831396 | 0.79 | HDAC1 (0.48) | HDAC1HDAC2MAPK1TOP1TOP2A | |
| SCHEMBL9320516 | 0.79 | HDAC1 (0.69) | HDAC1HDAC2HDAC3MAPK1TOP1 | |
| SCHEMBL24925441 | 0.78 | HDAC1 (0.54) | HDAC1HDAC2HDAC3MAPK1PTGS1 | |
| SCHEMBL8777972 | 0.78 | TOP1 (0.48) | TOP1TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |