Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661171 | 0.80 | TOP1 (0.57) | TOP1TOP2ATOP2BKMT2AMEN1 | |
| SCHEMBL9417251 | 0.79 | MEN1 (0.60) | KMT2AMEN1ALDH1A1GAAHPGD | |
| SCHEMBL11802443 | 0.79 | HPGD (0.59) | TOP1TOP2ATOP2BKMT2AMEN1 | |
| SCHEMBL8844428 | 0.78 | NPC1 (0.65) | TOP1TOP2ATOP2BALDH1A1GLA | |
| SCHEMBL8777865 | 0.78 | HDAC1 (0.58) | TOP1TOP2ATOP2B | |
| SCHEMBL11729947 | 0.77 | NSD2 (0.63) | KMT2AALDH1A1HPGDTNFRSF1AMAPT | |
| SCHEMBL8777987 | 0.75 | TRPV1 (0.49) | TOP1TOP2ATOP2BKMT2AMEN1 | |
| SCHEMBL9153729 | 0.74 | ALDH1A1 (0.43) | KMT2AMEN1ALDH1A1KDM4EGLA | |
| SCHEMBL8777841 | 0.74 | TACR1 (0.44) | TOP1TOP2ATOP2BALDH1A1CYP1A2 | |
| SCHEMBL10489758 | 0.74 | TRPV1 (0.47) | KMT2AMEN1ALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |