⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17278171 | 0.86 | TBXAS1 (0.31) | — | |
| SCHEMBL361354 | 0.81 | TBXAS1 (0.31) | — | |
| SCHEMBL4365358 | 0.78 | — | — | |
| SCHEMBL4326682 | 0.78 | — | — | |
| SCHEMBL6158210 | 0.78 | — | — | |
| SCHEMBL28241548 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL28305955 | 0.77 | NFKB1 (0.34) | — | |
| Bromide SCHEMBL29033775 | 0.73 | — | — | |
| SCHEMBL28815575 | 0.73 | LMNA (0.33) | — | |
| Allylamine SCHEMBL4925394 | 0.72 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2082041-B1 | NOVEL GENES RELATED TO GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2018-03-14 | — | — | EP | disclosed |
| EP-2635675-B1 | CRYSTAL STRUCTURE OF ISOGLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2016-01-06 | — | — | EP | disclosed |
| EP-2606129-B1 | CRYSTAL STRUCTURE OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2015-03-25 | — | — | EP | disclosed |
| US-8859250-B2 | Crystal structure of glutaminyl cyclase | PROBIODRUG AG (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8809010-B2 | Method for prophylactic treatment of alzheimer's disease using inhibitors of glutaminyl cyclase and glutamate cyclases | PROBIODRUG AG (DE) | 2014-08-19 | — | — | US | disclosed |
| US-8741614-B2 | Crystal structure of isoglutaminyl cyclase | PROBIODRUG AG (DE) | 2014-06-03 | — | — | US | disclosed |
| US-8647834-B2 | Screening method for enzyme inhibitors | PROBIODRUG AG (DE) | 2014-02-11 | — | — | US | disclosed |
| US-20130217090-A1 | CRYSTAL STRUCTURE OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2013-08-22 | — | — | US | disclosed |
| EP-2606129-A1 | CRYSTAL STRUCTURE OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2581449-A2 | Novel genes related to glutaminyl cyclase | Probiodrug AG (DE) | 2013-04-17 | — | — | EP | disclosed |
| US-20090018087-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2009-01-15 | — | — | US | disclosed |
| US-20080249083-A1 | NOVEL GENES RELATED TO GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2008-10-09 | — | — | US | disclosed |
| WO-2008104580-A1 | NEW USE OF GLUTAMINYL CYCLASE INHIBITORS | PROBIODRUG AG (DE) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008034891-A2 | NOVEL GENES RELATED TO GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2008-03-27 | — | — | WO | disclosed |
| US-7304086-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2007-12-04 | — | — | US | disclosed |
| US-20070191366-A1 | USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES | PROBIODRUG AG (DE) | 2007-08-16 | — | — | US | disclosed |
| CN-1918131-A | Novel inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2007-02-21 | — | — | CN | disclosed |
| EP-1713780-A2 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2006-10-25 | — | — | EP | disclosed |
| US-20050215573-A1 | Novel inhibitors of glutaminyl cyclase | PROBIODRUG AG | 2005-09-29 | — | — | US | disclosed |
| WO-2005075436-A2 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2005-08-18 | — | — | WO | disclosed |