Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.61 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122779 | 0.99 | NPC1 (0.64) | NPC1RAB9AEPHX2EPHX1TAS1R3 | |
| SCHEMBL2753348 | 0.85 | RAB9A (0.63) | NPC1RAB9AEPHX2EPHX1TAS1R3 | |
| SCHEMBL21230467 | 0.85 | TAS1R3 (0.71) | NPC1RAB9AEPHX2EPHX1TAS1R3 | |
| SCHEMBL8777820 | 0.80 | ALDH1A1 (0.62) | NPC1RAB9AEPHX2EPHX1MAPT | |
| SCHEMBL8777821 | 0.80 | RAB9A (0.77) | NPC1RAB9AEPHX2EPHX1MEN1 | |
| SCHEMBL8114736 | 0.79 | ALDH1A1 (0.64) | NPC1RAB9AEPHX2EPHX1MAPT | |
| SCHEMBL22720136 | 0.78 | RAB9A (0.58) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL20671206 | 0.78 | HTT (0.64) | NPC1RAB9AEPHX2EPHX1TAS1R3 | |
| SCHEMBL21931143 | 0.78 | KMT2A (0.55) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2751488 | 0.77 | NPC1 (0.97) | NPC1RAB9AEPHX2EPHX1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |