Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29376098 | 0.81 | EPHX1 (0.56) | EPHX1HTTSMN1; SMN2ALDH1A1ALOX12 | |
| SCHEMBL28694103 | 0.81 | EPHX1 (0.56) | EPHX1HTTSMN1; SMN2ALDH1A1ALOX12 | |
| SCHEMBL8596871 | 0.81 | LMNA (0.67) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8777838 | 0.80 | EPHX1 (0.55) | EPHX1HTTSMN1; SMN2ALDH1A1ALOX12 | |
| SCHEMBL9854361 | 0.80 | LMNA (0.56) | LMNAALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL29908348 | 0.80 | RAB9A (0.69) | LMNAHTTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8600968 | 0.79 | KMT2A (0.50) | LMNAHTTALDH1A1KMT2AALOX12 | |
| SCHEMBL29128667 | 0.75 | LMNA (0.50) | LMNAHTTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9687003 | 0.75 | LMNA (0.54) | LMNAHTTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL14099477 | 0.74 | MAPT (0.68) | LMNAHTTSMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |