Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777955 | 0.81 | HDAC1 (0.60) | SOAT1PPARGPPARA | |
| SCHEMBL8777853 | 0.79 | EPHX2 (0.57) | KCNMA1MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL13811051 | 0.75 | ICMT (0.57) | MAPTMAPK1ALDH1A1PPARGPPARA | |
| SCHEMBL4060607 | 0.74 | HCAR3 (0.52) | MAPTTDP1NPSR1ALDH1A1HCAR3 | |
| SCHEMBL4060610 | 0.74 | HCAR3 (0.52) | MAPTTDP1NPSR1ALDH1A1HCAR3 | |
| SCHEMBL8135625 | 0.74 | KCNMA1 (0.55) | KCNMA1MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL1170111 | 0.74 | HCAR3 (0.66) | MAPTMAPK1ALDH1A1HCAR3LMNA | |
| SCHEMBL30585155 | 0.73 | MAPT (0.64) | KCNMA1MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL571816 | 0.73 | MAPT (0.64) | KCNMA1MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL1266704 | 0.72 | KCNMA1 (0.62) | KCNMA1MAPTMAPK1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |