Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8778076 | 0.81 | KCNMA1 (0.46) | SOAT1PPARGPPARA | |
| SCHEMBL13811051 | 0.79 | ICMT (0.57) | HDAC1HDAC3HTTPPARGPPARA | |
| SCHEMBL27757715 | 0.79 | HDAC1 (0.62) | HDAC1HDAC3 | |
| SCHEMBL2618087 | 0.78 | HDAC1 (0.64) | HDAC1HDAC3 | |
| SCHEMBL8777922 | 0.77 | EPHX2 (0.66) | HDAC1HDAC3HTT | |
| SCHEMBL1937892 | 0.75 | HDAC1 (1.00) | HDAC1HDAC3 | |
| SCHEMBL8777844 | 0.74 | SOAT1 (0.44) | HDAC1HDAC3SOAT1PPARGPPARA | |
| SCHEMBL9152529 | 0.74 | SOAT1 (0.67) | SOAT1PPARGPPARAPPARDSOAT2 | |
| SCHEMBL9257327 | 0.73 | SOAT1 (0.86) | SOAT1PPARGPPARAPPARDSOAT2 | |
| SCHEMBL9157883 | 0.73 | SOAT1 (0.66) | SOAT1PPARGPPARAPPARDSOAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |