Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11839434 | 0.79 | L3MBTL1 (0.56) | KDM4EGAAHPGDPOLBALDH1A1 | |
| SCHEMBL8085823 | 0.78 | POLB (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4966437 | 0.74 | POLB (0.54) | KDM4EGAAHPGDPOLBALDH1A1 | |
| SCHEMBL20848220 | 0.74 | POLB (0.54) | KDM4EGAAHPGDPOLBALDH1A1 | |
| SCHEMBL4966443 | 0.74 | POLB (0.54) | KDM4EGAAHPGDPOLBALDH1A1 | |
| SCHEMBL2729166 | 0.65 | DDB1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11842287 | 0.64 | KDM4E (0.61) | KDM4EGAAHPGDPOLBALDH1A1 | |
| SCHEMBL10798008 | 0.64 | HPGD (0.44) | GAAHPGDALDH1A1 | |
| SCHEMBL20848252 | 0.64 | POLB (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20848255 | 0.64 | GAA (0.41) | KDM4EGAAHPGDPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802923-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1995035311-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |