Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877923 | 0.86 | F10 (0.37) | POLBKDM4AKDM4CDRD2JAK2 | |
| SCHEMBL15589877 | 0.80 | OPRD1 (0.34) | POLBKDM4AKDM4CDRD2JAK2 | |
| SCHEMBL877832 | 0.79 | POLB (0.32) | POLBKDM4AKDM4CDRD2JAK2 | |
| SCHEMBL785318 | 0.73 | POLB (0.40) | POLBDRD2ACACBOPRD1 | |
| SCHEMBL784917 | 0.73 | WDR5 (0.39) | JAK2JAK1ACACB | |
| SCHEMBL876280 | 0.71 | F10 (0.39) | POLBKDM4AKDM4CDRD2MCHR1 | |
| SCHEMBL784916 | 0.71 | ACACB (0.35) | POLBDRD2JAK2JAK1ACACB | |
| SCHEMBL785043 | 0.71 | POLB (0.40) | POLBDRD2ACACBMCHR1 | |
| SCHEMBL27920407 | 0.71 | CA12 (0.40) | POLBDRD2KCNH2 | |
| SCHEMBL784165 | 0.70 | ALDH1A1 (0.41) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | claimed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | claimed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |