Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | KDM4A | O75164 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15589877 | 0.90 | OPRD1 (0.34) | POLBOPRD1KCNH2EGLN1DRD2 | |
| SCHEMBL877924 | 0.87 | F10 (0.36) | POLBEGLN1DRD2KDM4AKDM4C | |
| SCHEMBL877831 | 0.79 | POLB (0.34) | POLBOPRD1KCNH2DRD2ACACB | |
| SCHEMBL876281 | 0.74 | F10 (0.37) | POLBDRD2KDM4AKDM4C | |
| SCHEMBL878301 | 0.74 | CCR5 (0.35) | POLBDRD2MCHR1JAK2JAK1 | |
| SCHEMBL784917 | 0.73 | WDR5 (0.39) | EGLN1ACACBJAK2JAK1 | |
| SCHEMBL785318 | 0.72 | POLB (0.40) | POLBOPRD1DRD2ACACB | |
| SCHEMBL785043 | 0.70 | POLB (0.40) | POLBDRD2ACACBMCHR1 | |
| SCHEMBL784916 | 0.70 | ACACB (0.35) | POLBDRD2ACACBJAK2JAK1 | |
| SCHEMBL27920407 | 0.70 | CA12 (0.40) | POLBKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | claimed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | claimed |