Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779252 | 0.94 | CARM1 (0.34) | AAK1CARM1PRMT6MAPTGSK3B | |
| SCHEMBL8779232 | 0.89 | GSK3B (0.39) | AAK1CARM1PRMT6MAPTGSK3B | |
| SCHEMBL8779221 | 0.87 | HTT (0.38) | AAK1CARM1PRMT6MAPTGSK3B | |
| SCHEMBL8779408 | 0.84 | CARM1 (0.30) | CARM1 | |
| SCHEMBL8882129 | 0.83 | MAPT (0.34) | AAK1CARM1PRMT6MAPTGSK3B | |
| SCHEMBL8779176 | 0.82 | HPGD (0.38) | AAK1CARM1PRMT6 | |
| SCHEMBL8779212 | 0.82 | HPGD (0.38) | AAK1CARM1PRMT6 | |
| SCHEMBL8779292 | 0.82 | CARM1 (0.35) | AAK1CARM1PRMT6CYP3A4 | |
| SCHEMBL8779316 | 0.81 | MME (0.39) | — | |
| SCHEMBL8779325 | 0.81 | IKBKB (0.37) | CARM1PRMT6MAPTACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |