Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779232 | 0.90 | GSK3B (0.39) | MAPTCARM1PRMT6AAK1CYP2C9 | |
| SCHEMBL8779252 | 0.88 | CARM1 (0.34) | MAPTCARM1PRMT6AAK1GSK3B | |
| SCHEMBL8779141 | 0.87 | AAK1 (0.33) | MAPTCARM1PRMT6AAK1GSK3B | |
| SCHEMBL9233029 | 0.85 | KMT2A (0.41) | HTTKMT2ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL8779212 | 0.83 | HPGD (0.38) | KMT2ASMN1; SMN2KDM4ECARM1PRMT6 | |
| SCHEMBL8779176 | 0.83 | HPGD (0.38) | KMT2ASMN1; SMN2KDM4ECARM1PRMT6 | |
| SCHEMBL8883898 | 0.83 | KMT2A (0.39) | HTTKMT2ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL8779292 | 0.82 | CARM1 (0.35) | SMN1; SMN2CARM1PRMT6AAK1CYP3A4 | |
| SCHEMBL8779316 | 0.82 | MME (0.39) | — | |
| SCHEMBL8779136 | 0.81 | IKBKB (0.37) | SMN1; SMN2MAPTKDM4ECARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |