Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779413 | 0.79 | ESR1 (0.51) | — | |
| SCHEMBL8882451 | 0.75 | EGLN1 (0.63) | EGLN1EGLN3FLT1VEGFA | |
| SCHEMBL4070937 | 0.74 | FTO (0.57) | EGLN1FTOEGLN2EGLN3 | |
| SCHEMBL7358042 | 0.72 | PTGS2 (0.50) | — | |
| SCHEMBL16532809 | 0.71 | APP (0.38) | — | |
| SCHEMBL8786035 | 0.70 | HSD17B2 (0.43) | — | |
| SCHEMBL6563671 | 0.69 | KDM4C (0.48) | EGLN1FTOEGLN2EGLN3 | |
| SCHEMBL8787902 | 0.69 | TP53 (0.48) | — | |
| SCHEMBL8785210 | 0.68 | KDM4E (0.45) | — | |
| SCHEMBL8784776 | 0.67 | MAPT (0.42) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |