Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 3/20 | 0.57 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779171 | 0.84 | EGLN2 (0.46) | FTOEGLN2GAAEGLN1ALDH1A1 | |
| SCHEMBL7611607 | 0.82 | EGLN2 (0.39) | FTOEGLN2GAAALDH1A1L3MBTL1 | |
| SCHEMBL8374641 | 0.81 | GAA (0.46) | FTOEGLN2GAAEGLN1ALDH1A1 | |
| SCHEMBL7610436 | 0.81 | EGLN2 (0.38) | FTOEGLN2GAAEGLN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8809536 | 0.80 | GAA (0.45) | FTOEGLN2GAAEGLN1ALDH1A1 | |
| SCHEMBL7611608 | 0.80 | FAAH (0.41) | FTOEGLN2ALDH1A1FAAH | |
| SCHEMBL7606839 | 0.78 | FAAH (0.47) | GAAL3MBTL1FAAH | |
| SCHEMBL7607577 | 0.77 | KDM4E (0.45) | FAAH | |
| SCHEMBL7608635 | 0.77 | CYP19A1 (0.45) | FTOEGLN2ALDH1A1FAAH | |
| SCHEMBL2304200 | 0.77 | FTO (0.41) | FTOEGLN2EGLN1KDM2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | claimed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | claimed |
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |