Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.58 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9593578 | 0.87 | ABL1 (0.60) | ALDH1A1POLBRAB9AABCC8KCNJ11 | |
| SCHEMBL8779355 | 0.86 | RAB9A (0.70) | ALDH1A1POLBRAB9AABCC8KCNJ11 | |
| SCHEMBL9593548 | 0.80 | MAPK1 (0.66) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL12297933 | 0.79 | ABL1 (0.71) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL9403495 | 0.78 | SMN1; SMN2 (0.56) | ALDH1A1POLBRAB9AABCC8KCNJ11 | |
| SCHEMBL8779366 | 0.77 | ABL1 (0.84) | ALDH1A1RAB9AABCC8KCNJ11MEN1 | |
| SCHEMBL25387786 | 0.76 | ALDH1A1 (0.74) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL8779318 | 0.75 | ABL1 (0.65) | ALDH1A1POLBRAB9AABCC8KCNJ11 | |
| SCHEMBL8779385 | 0.73 | MEN1 (0.58) | ALDH1A1POLBABCC8KCNJ11MEN1 | |
| SCHEMBL7479383 | 0.73 | EPHX2 (0.62) | ALDH1A1RAB9AMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | disclosed |
| US-5401853-A | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.R.L. (IT) | 1995-03-28 | — | — | US | disclosed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | disclosed |