Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.65 |
| ▸ | SRC | P12931 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.63 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779355 | 0.83 | RAB9A (0.70) | ABL1SRCKMT2AMEN1KDM4E | |
| SCHEMBL3612969 | 0.83 | SMN1; SMN2 (0.76) | ABL1SRCKMT2AMEN1KDM4E | |
| SCHEMBL8779366 | 0.82 | ABL1 (0.84) | ABL1SRCKMT2AMEN1KDM4E | |
| SCHEMBL28451175 | 0.81 | ABL1 (0.67) | ABL1SRCKMT2AMEN1KDM4E | |
| SCHEMBL28415513 | 0.80 | ABCC8 (0.56) | ABL1SRCKMT2AMEN1KDM4E | |
| SCHEMBL7483795 | 0.78 | MEN1 (0.65) | ABL1SRCKMT2AMEN1KDM4E | |
| SCHEMBL9593578 | 0.76 | ABL1 (0.60) | ABL1SRCKMT2AMEN1KDM4E | |
| SCHEMBL601080 | 0.76 | DGAT1 (1.00) | ABL1SRCDGAT1 | |
| SCHEMBL601079 | 0.76 | DGAT1 (1.00) | ABL1SRCDGAT1 | |
| SCHEMBL8779385 | 0.75 | MEN1 (0.58) | ABL1SRCKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | disclosed |
| US-5401853-A | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.R.L. (IT) | 1995-03-28 | — | — | US | disclosed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | disclosed |