Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779353 | 0.86 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2TSHRHTT | |
| SCHEMBL8779317 | 0.83 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2TSHRHTT | |
| SCHEMBL8779338 | 0.80 | NPC1 (0.65) | RAB9ANPC1SMN1; SMN2TSHRHTT | |
| SCHEMBL8779299 | 0.78 | NPC1 (0.54) | RAB9ANPC1SMN1; SMN2TSHRHTT | |
| SCHEMBL8779311 | 0.71 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2TSHRHTT | |
| SCHEMBL8779375 | 0.70 | TOP1 (0.37) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL14426475 | 0.68 | LMNA (0.74) | RAB9ANPC1SMN1; SMN2TSHRHTT | |
| SCHEMBL3547447 | 0.67 | ALDH1A1 (0.64) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16150878 | 0.67 | LCK (0.61) | RAB9ANPC1SMN1; SMN2TSHRHTT | |
| SCHEMBL8779275 | 0.66 | NPC1 (0.62) | RAB9ANPC1SMN1; SMN2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |