SCHEMBL8779336

SCHEMBL8779336

O=Cc1ccc(N2CCN(CCO)CC2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.62
TRIM24 O15164 1/20 0.58
TRIM33 Q9UPN9 1/20 0.58
SMN1; SMN2 Q16637 2/20 0.56
KDM4E B2RXH2 1/20 0.56
HTR7 P34969 2/20 0.44
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
KCNH2 Q12809 1/20 0.42
BCL2A1 Q16548 1/20 0.42
DRD2 P14416 3/20 0.42
HTR1A P08908 1/20 0.42
DRD3 P35462 1/20 0.42
RORC P51449 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
USP2 O75604 1/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
MAPT P10636 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19601373 0.90 ALDH1A1 (0.58) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL28367239 0.88 ALDH1A1 (0.49) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL28367241 0.88 ALDH1A1 (0.49) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL9354477 0.85 ALDH1A1 (0.53) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL19601242 0.83 ALDH1A1 (0.57) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL1983610 0.82 ALDH1A1 (0.60) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL3077544 0.82 TRIM24 (0.83) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL2561698 0.82 TRIM24 (0.83) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL377522 0.81 ALDH1A1 (0.63) ALDH1A1TRIM24TRIM33SMN1; SMN2KDM4E
SCHEMBL15768383 0.80 PKM (0.53) ALDH1A1KDM4EMEN1KMT2ASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552779-B2 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-on and derivative thereof, preparation method therefor, and composition comprising same for preventing, alleviating or treating neurodegenerative diseases DUKSUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2026-02-17 US disclosed
US-20240358679-A1 PHARMACEUTICAL AND FOOD COMPOSITIONS FOR THE PREVENTION, ALLEVIATION, OR TREATMENT OF INFLAMMATORY DISEASES COMPRISING 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDIN-4-ONE AND ITS DERIVATIVES INDUSTRY ACADEMIC COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY (KR) 2024-10-31 US disclosed
US-20230286956-A1 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES KNU- INDUSTRY COOPERATION FOUNDATION (KR) 2023-09-14 US disclosed
WO-2023132681-A1 PHARMACEUTICAL COMPOSITION AND FOOD COMPOSITION COMPRISING 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDIN-4-ONE AND DERIVATIVE THEREOF FOR PREVENTION, ALLEVIATION, OR TREATMENT OF INFLAMMATORY DISEASE 덕성여자대학교 산학협력단 2023-07-13 WO disclosed
EP-4183776-A1 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES Duksung Women's University Industry-Academic Cooperation Foundation (KR) 2023-05-24 EP disclosed
EP-3481824-B1 2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY KANCERA AB (SE) 2021-10-20 EP disclosed
CN-109563092-B 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 坎塞拉有限公司 2021-09-14 CN disclosed
CN-104693199-A 2,9-bis-styryl substituted phenanthroline compounds, and preparation method and application thereof CHINESE ACAD INST CHEMISTRY 2015-06-10 CN disclosed
EP-1831168-B1 PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY PROTEIN KINASES FOR THE TREATMENT OF INFLAMMATORY, PROLIFERATIVE AND IMMUNOLOGICALLY-MEDIATED DISEASES. VERTEX PHARMA (US) 2014-07-02 EP disclosed
EP-0805814-A1 POLYMERISABLE OR POLYCONDENSABLE PHOSPHINE OXIDE, POLYMERS OBTAINED THEREFROM, AND USE THEREOF IN NON-LINEAR OPTICS AND ELECTRO-OPTICS COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1997-11-12 EP disclosed
WO-1996022993-A1 POLYMERISABLE OR POLYCONDENSABLE PHOSPHINE OXIDE, POLYMERS OBTAINED THEREFROM, AND USE THEREOF IN NON-LINEAR OPTICS AND ELECTRO-OPTICS COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1996-08-01 WO disclosed
EP-0621962-A1 FUNCTIONALIZED MEROCYANINE DYES AND POLYMERS INCORPORATING SUCH DYES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-02 EP disclosed
US-5256784-A Merocyanine dyes MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-10-26 US disclosed
WO-1993015596-A2 FUNCTIONALIZED MEROCYANINE DYES AND POLYMERS INCORPORATING SUCH DYES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12552779-B2 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-on and derivative thereof, preparation method therefor, and composition comprising same for preventing, alleviating or treating neurodegenerative diseases SNCA, HTT, PSEN1 ALDH1A1 516/4885TRIM24 2148/4885TRIM33 3746/4885
US-20230286956-A1 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES PSEN2, PARK7, SNCA ALDH1A1 1091/4885TRIM24 1272/4885TRIM33 2950/4885
US-20240358679-A1 PHARMACEUTICAL AND FOOD COMPOSITIONS FOR THE PREVENTION, ALLEVIATION, OR TREATMENT OF INFLAMMATORY DISEASES COMPRISING 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDIN-4-ONE AND ITS DERIVATIVES GPX4, GPX1, SELENOI ALDH1A1 1204/4885TRIM24 933/4885TRIM33 1519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.