Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | G6PD | P11413 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GLS | O94925 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10892136 | 0.83 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL28608986 | 0.82 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL10878301 | 0.82 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2RAB9AALOX15CYP1A2 | |
| SCHEMBL8779354 | 0.80 | RAB9A (0.59) | ALDH1A1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL19370459 | 0.79 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2RAB9AALOX15CYP1A2 | |
| SCHEMBL9086956 | 0.79 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2RAB9ANPC1ALOX15 | |
| SCHEMBL629408 | 0.77 | CA1 (0.62) | ALDH1A1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL5181389 | 0.76 | SMN1; SMN2 (0.69) | ALDH1A1SMN1; SMN2RAB9ANPC1ALOX15 | |
| SCHEMBL11723544 | 0.76 | RAB9A (0.57) | ALDH1A1SMN1; SMN2RAB9ANPC1POLB | |
| SCHEMBL11117150 | 0.75 | SMN1; SMN2 (0.58) | ALDH1A1SMN1; SMN2RAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |