Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11741095 | 0.85 | GPR35 (0.52) | KCNQ2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL2942491 | 0.84 | KCNQ2 (0.50) | KCNQ2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL3648636 | 0.84 | ALDH1A1 (0.57) | KCNQ2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL5604538 | 0.83 | POLB (0.61) | MAPTTP53GAANPC1RAB9A | |
| SCHEMBL20057526 | 0.82 | ALDH1A1 (0.49) | KCNQ2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL11775098 | 0.82 | KCNQ2 (0.52) | KCNQ2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL29955273 | 0.82 | KCNQ2 (0.56) | KCNQ2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL20324021 | 0.81 | ALDH1A1 (0.68) | KCNQ2ALDH1A1TSHRSMN1; SMN2MAPT | |
| SCHEMBL10669191 | 0.79 | ALDH1A1 (0.59) | KCNQ2ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL29951744 | 0.79 | CYP2C19 (0.56) | KCNQ2SMN1; SMN2MAPTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0525197-A1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOG | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-03 | — | — | EP | disclosed |