Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780789 | 0.97 | ADORA2A (0.41) | HRH3APPKDM4EPKMADORA3 | |
| SCHEMBL8780940 | 0.90 | ADORA2A (0.43) | SIGMAR1PKMADORA3ADORA2AADORA2B | |
| SCHEMBL8780776 | 0.89 | MAOA (0.37) | MAOBPKMADORA3ADORA2AADORA2B | |
| SCHEMBL8780869 | 0.87 | KCNH2 (0.42) | KDM4EADORA1KCNH2 | |
| SCHEMBL8780903 | 0.86 | KCNH2 (0.38) | SIGMAR1ADORA1KCNH2 | |
| SCHEMBL8780892 | 0.85 | RXFP1 (0.42) | HRH3APPADORA3ADORA2AADORA2B | |
| SCHEMBL8780829 | 0.85 | RIPK2 (0.43) | HRH3KDM4ESIGMAR1MAOBADORA3 | |
| SCHEMBL8780990 | 0.85 | KCNH2 (0.39) | PKMADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL8780851 | 0.85 | KCNH2 (0.55) | HRH3PKMKCNH2 | |
| SCHEMBL8780988 | 0.84 | KCNH2 (0.41) | KDM4EADORA1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |