Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451239 | 0.94 | CYP2D6 (0.44) | CHRM1KDM4ECYP2D6GAAMEN1 | |
| SCHEMBL7037673 | 0.83 | CHRM1 (0.45) | CHRM1KDM4ECHRM3 | |
| SCHEMBL7457776 | 0.79 | CYP2D6 (0.44) | CHRM1KDM4ECYP2D6GAAMEN1 | |
| SCHEMBL7456380 | 0.76 | CHRM1 (0.44) | CHRM1KDM4ECHRM2CHRM5CHRM3 | |
| SCHEMBL4086184 | 0.72 | CYP2C19 (0.53) | CYP2D6LMNAPOLB | |
| SCHEMBL8582632 | 0.72 | CYP2C19 (0.53) | CYP2D6LMNAPOLB | |
| SCHEMBL12744721 | 0.67 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL7041710 | 0.67 | ALDH1A1 (0.57) | CHRM1KDM4EGAACHRM3MEN1 | |
| SCHEMBL5257603 | 0.66 | KMT2A (0.55) | GAAMEN1LMNAKMT2A | |
| SCHEMBL1463674 | 0.66 | CHRNA4 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782574-A1 | BICYCLIC CARBOXAMIDES AS 5-HT 1A? ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| US-5610154-A | ANXIOLYTIC AGENTS | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |
| WO-1996009302-A1 | BICYCLIC CARBOXAMIDES AS 5-HT1A ANTAGONISTS | JOHN WYETH & BROTHER LTD. (GB) | 1996-03-28 | — | — | WO | disclosed |