Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451239 | 0.85 | CYP2D6 (0.44) | CHRM1ALDH1A1KDM4E | |
| SCHEMBL7041710 | 0.84 | ALDH1A1 (0.57) | CHRM1CHRM3ALDH1A1KDM4E | |
| SCHEMBL8781410 | 0.83 | CHRM1 (0.40) | CHRM1CHRM3KDM4E | |
| SCHEMBL7456380 | 0.79 | CHRM1 (0.44) | CHRM1CHRM3ALDH1A1KDM4E | |
| SCHEMBL20343486 | 0.76 | LMNA (0.44) | CHRM1CHRM3 | |
| SCHEMBL8582632 | 0.72 | CYP2C19 (0.53) | ALDH1A1 | |
| SCHEMBL4086184 | 0.72 | CYP2C19 (0.53) | ALDH1A1 | |
| SCHEMBL7108946 | 0.71 | CHRM1 (0.40) | CHRM1ALDH1A1KDM4E | |
| SCHEMBL7453383 | 0.71 | HTR1A (0.78) | ALDH1A1KDM4E | |
| SCHEMBL7457776 | 0.71 | CYP2D6 (0.44) | CHRM1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037637-B1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | UNIV PRINCETON (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-0782574-B1 | BICYCLIC CARBOXAMIDES AS 5-HT1A RECEPTORS LIGANDS | WYETH JOHN & BROTHER LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| EP-1037637-A1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | PRINCETON UNIVERSITY (US) | 2000-09-27 | — | — | EP | disclosed |
| US-5919802-A | Methods of preventing and/or treating temporal lobe epilepsy | PRINCETON UNIVERSITY (US) | 1999-07-06 | — | — | US | disclosed |
| WO-1999029323-A1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | PRINCETON UNIVERSITY (US) | 1999-06-17 | — | — | WO | disclosed |
| EP-0782574-A1 | BICYCLIC CARBOXAMIDES AS 5-HT 1A? ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| US-5610154-A | ANXIOLYTIC AGENTS | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |
| WO-1996009302-A1 | BICYCLIC CARBOXAMIDES AS 5-HT1A ANTAGONISTS | JOHN WYETH & BROTHER LTD. (GB) | 1996-03-28 | — | — | WO | disclosed |