Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | BCHE | P06276 | 9/20 | 0.45 |
| ▸ | ACHE | P22303 | 9/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | FABP1 | P07148 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495989 | 0.79 | KDM4E (0.82) | KDM4EBCHEACHEHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8984092 | 0.78 | KDM4E (0.80) | KDM4EBCHEACHEHSD17B10ALDH1A1 | |
| SCHEMBL9875385 | 0.75 | KDM4E (0.54) | KDM4EBCHEACHEHSD17B10ALDH1A1 | |
| SCHEMBL8791193 | 0.75 | KDM4E (0.57) | KDM4EBCHEACHEHSD17B10ALDH1A1 | |
| SCHEMBL7283199 | 0.71 | KDM4E (0.53) | KDM4EBCHEACHEHSD17B10ALDH1A1 | |
| SCHEMBL8984077 | 0.71 | KMT2A (0.67) | KDM4EBCHEACHEKMT2AHTT | |
| SCHEMBL28193792 | 0.71 | ALDH1A1 (0.50) | KDM4EACHEHSD17B10ALDH1A1TSHR | |
| SCHEMBL9875611 | 0.70 | BCHE (0.53) | KDM4EBCHEACHEALDH1A1APP | |
| SCHEMBL9875231 | 0.70 | BCHE (0.64) | KDM4EBCHEACHEKMT2AHTT | |
| SCHEMBL9875563 | 0.69 | KDM4E (0.68) | KDM4EBCHEACHEHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499231-B1 | 9-Aminotetrahydroacridines and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-05-21 | — | — | EP | disclosed |
| US-5502203-A | FOR ACRIDINE COMPOUNDS USED IN TREATMENT OF ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-03-26 | — | — | US | disclosed |
| US-5382594-A | Cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-01-17 | — | — | US | disclosed |
| US-5210087-A | Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-11 | — | — | US | disclosed |
| EP-0499231-A1 | 9-Aminotetrahydroacridines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-08-19 | — | — | EP | disclosed |