Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942260 | 0.84 | FURIN (0.39) | F10ALDH1A1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8783271 | 0.83 | SIGMAR1 (0.57) | ALDH1A1KMT2AHTTSMN1; SMN2SIGMAR1 | |
| SCHEMBL8782783 | 0.83 | GAA (0.57) | F10KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL8783388 | 0.81 | ALOX5 (0.48) | F10ALDH1A1KMT2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL8783708 | 0.81 | SMPD1 (0.60) | F10KMT2AMEN1 | |
| SCHEMBL8783294 | 0.80 | MEN1 (0.57) | F10ALDH1A1KMT2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL24002294 | 0.79 | SMN1; SMN2 (0.52) | F10ALDH1A1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8782791 | 0.79 | GAA (0.51) | ALDH1A1KMT2AHTTSMN1; SMN2SIGMAR1 | |
| SCHEMBL8783047 | 0.77 | ALOX5 (0.50) | F10ALDH1A1KMT2ASIGMAR1ALOX5 | |
| SCHEMBL203154 | 0.76 | PARP1 (0.58) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |
| US-5214204-A | Inhibitors of biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |