Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782791 | 0.92 | GAA (0.51) | SIGMAR1ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL8783388 | 0.88 | ALOX5 (0.48) | SIGMAR1ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL8783294 | 0.86 | MEN1 (0.57) | SIGMAR1ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8782783 | 0.84 | GAA (0.57) | GAAMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8783847 | 0.84 | NPC1 (0.61) | SIGMAR1ALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL28037490 | 0.84 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL8782827 | 0.83 | F10 (0.46) | SIGMAR1ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL8783047 | 0.83 | ALOX5 (0.50) | SIGMAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL8782586 | 0.82 | SNCA (0.49) | ALDH1A1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8783708 | 0.82 | SMPD1 (0.60) | KMT2AMEN1NPC1RAB9ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |