Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782837 | 1.00 | ALDH1A1 (0.65) | ALDH1A1LMNASMN1; SMN2ALOX5HDAC8 | |
| SCHEMBL9484229 | 0.85 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2ALOX5NPC1 | |
| SCHEMBL8942682 | 0.84 | SMN1; SMN2 (0.53) | ALDH1A1LMNASMN1; SMN2ALOX5HDAC8 | |
| SCHEMBL8783528 | 0.82 | KDM4E (0.57) | ALDH1A1LMNASMN1; SMN2ALOX5MEN1 | |
| SCHEMBL8783536 | 0.82 | KDM4E (0.57) | ALDH1A1LMNASMN1; SMN2ALOX5MEN1 | |
| SCHEMBL8942436 | 0.80 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2ALOX5HDAC8 | |
| SCHEMBL8248607 | 0.79 | ALDH1A1 (0.72) | ALDH1A1LMNASMN1; SMN2HDAC8NPC1 | |
| SCHEMBL8782857 | 0.79 | HDAC8 (0.57) | ALDH1A1LMNASMN1; SMN2ALOX5HDAC8 | |
| SCHEMBL8783449 | 0.78 | ALOX5 (0.57) | ALDH1A1LMNASMN1; SMN2ALOX5HDAC8 | |
| SCHEMBL8783294 | 0.77 | MEN1 (0.57) | ALDH1A1LMNASMN1; SMN2ALOX5HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0595995-A4 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0595995-A1 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1994-05-11 | — | — | EP | disclosed |
| US-5214204-A | Inhibitors of biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| WO-1993002037-A1 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1993-02-04 | — | — | WO | disclosed |