Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942600 | 0.84 | KDM4E (0.46) | NPC1RAB9ACNR2KDM4ESCN3A | |
| SCHEMBL8782677 | 0.76 | CYP1A2 (0.61) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL8942396 | 0.71 | VEGFA (0.57) | NPC1RAB9ACNR2KDM4ESCN3A | |
| SCHEMBL31590800 | 0.70 | VEGFA (0.55) | NPC1RAB9ACNR2KDM4ESCN3A | |
| SCHEMBL6992210 | 0.70 | CNR2 (0.64) | NPC1RAB9ACNR2KDM4ESCN3A | |
| SCHEMBL12803579 | 0.69 | VEGFA (0.51) | NPC1RAB9ACNR2KDM4ESCN3A | |
| SCHEMBL8783029 | 0.69 | ALDH1A1 (0.50) | RAB9AKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL9373411 | 0.68 | AOC3 (0.56) | CNR2KDM4ECNR1ALDH1A1MEN1 | |
| SCHEMBL7186933 | 0.67 | FEN1 (0.51) | NPC1RAB9ACNR2KDM4ESCN3A | |
| SCHEMBL8782586 | 0.67 | SNCA (0.49) | NPC1RAB9AALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |
| US-5214204-A | Inhibitors of biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |