Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783180 | 1.00 | HTR2C (0.39) | HTR2CCHRNB2CHRNA4ALDH1A1LMNA | |
| SCHEMBL8782808 | 0.83 | HTR2C (0.47) | HTR2CALDH1A1MAPTSMN1; SMN2HTR2A | |
| SCHEMBL8782814 | 0.83 | HTR2C (0.47) | HTR2CALDH1A1MAPTSMN1; SMN2HTR2A | |
| SCHEMBL8782802 | 0.83 | HTR2C (0.47) | HTR2CALDH1A1MAPTSMN1; SMN2HTR2A | |
| SCHEMBL8783843 | 0.72 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTSMN1; SMN2ACHE | |
| SCHEMBL8783839 | 0.72 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTSMN1; SMN2ACHE | |
| SCHEMBL14781348 | 0.68 | ACHE (0.50) | HTR2CALDH1A1ACHEHTR2AHTR2B | |
| SCHEMBL318191 | 0.68 | MTNR1A (0.42) | HTR2CALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL10109118 | 0.68 | MTNR1A (0.42) | HTR2CALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL17365878 | 0.67 | ACHE (0.59) | ALDH1A1LMNAMAPTSMN1; SMN2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556119-B1 | Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them | ADIR (FR) | 1997-05-14 | — | — | EP | disclosed |
| US-5407946-A | Pyrrolidine compounds which are useful as thromboxane AZ-inhibitors | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |
| US-5387591-A | Possesses antithromboxane A2 properties; useful in treatment and prevention of thrombotic diseases | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0556119-A1 | Novel pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them | ADIR ET COMPAGNIE (FR) | 1993-08-18 | — | — | EP | disclosed |