Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 7/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785764 | 0.85 | WDR5 (0.43) | TAS1R3TAS1R1TAS1R2HPGDSP2RX7 | |
| SCHEMBL785763 | 0.85 | WDR5 (0.43) | TAS1R3TAS1R1TAS1R2HPGDSP2RX7 | |
| SCHEMBL803716 | 0.83 | PDE4A (0.43) | PDE10ATAS1R3TAS1R1TAS1R2HPGDS | |
| SCHEMBL803693 | 0.83 | PDE4A (0.43) | PDE10ATAS1R3TAS1R1TAS1R2HPGDS | |
| SCHEMBL878469 | 0.79 | ALDH1A1 (0.58) | PDE10AACHETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL875980 | 0.79 | ALDH1A1 (0.58) | PDE10AACHETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL875578 | 0.78 | ACHE (0.46) | PDE10AACHETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL785107 | 0.72 | WDR5 (0.37) | PDE10AWDR5HDAC6ACKR3 | |
| SCHEMBL877933 | 0.71 | ACHE (0.50) | ACHE | |
| SCHEMBL2817155 | 0.69 | PDE4A (0.45) | TAS1R3TAS1R1TAS1R2HPGDSP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |