Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | SNCA | P37840 | 10/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784080 | 0.88 | HTR1A (0.60) | HTR1AHTR2CLTA4HPLA2G2ATRPM8 | |
| SCHEMBL8789484 | 0.85 | HTR1A (0.49) | HTR1AHTR2CSNCALTA4HPLA2G2A | |
| SCHEMBL8784222 | 0.80 | HTR1A (0.58) | HTR1AHTR2CLTA4HPLA2G2ATRPM8 | |
| SCHEMBL8784168 | 0.79 | HTR1A (0.60) | HTR1AHTR2CSNCALTA4HPLA2G2A | |
| SCHEMBL7334188 | 0.77 | TRPV1 (0.65) | SNCALTA4HPLA2G2ATRPM8FAAH | |
| SCHEMBL8786780 | 0.77 | FAAH (0.52) | HTR1ALTA4HPLA2G2ATRPM8FAAH | |
| SCHEMBL8806792 | 0.77 | TRPV1 (0.53) | HTR1ALTA4HPLA2G2ATRPM8FAAH | |
| SCHEMBL8783944 | 0.77 | TRPV1 (0.46) | HTR1ASNCALTA4HPLA2G2ATRPM8 | |
| SCHEMBL8807001 | 0.76 | TRPV1 (0.53) | HTR1ALTA4HPLA2G2ATRPM8FAAH | |
| SCHEMBL8113405 | 0.76 | TRPV1 (0.53) | HTR1ALTA4HPLA2G2ATRPM8FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497512-B1 | Imidazole, triazole and tetrazole derivatives | MERCK SHARP & DOHME (GB) | 1997-09-24 | — | — | EP | disclosed |
| EP-0778275-A1 | Process for the preparation of imidazole, triazole and tetrazole derivatives and their use as selective 5-HT-1 receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 1997-06-11 | — | — | EP | disclosed |
| US-5602163-A | SELECTIVE AGONISTS OF 5-HYDROXYTRYPTAMINE RECEPTORS; USEFUL IN TREATMENT OF MIGRAINE HEADACHES | MERCK, SHARP & DOHME LTD. (GB) | 1997-02-11 | — | — | US | disclosed |
| US-5602162-A | TREATMENT AND/OR PREVENTION OF MIGRAINE | MERCK, SHARP & DOHME LTD. (GB) | 1997-02-11 | — | — | US | disclosed |
| US-5451588-A | Treatment of migraines | MERCK SHARP & DOHME LTD. (GB) | 1995-09-19 | — | — | US | disclosed |
| US-5298520-A | Triazole containing indole derivatives | MERCK SHARP & DOHME LIMITED (GB) | 1994-03-29 | — | — | US | disclosed |
| EP-0497512-A2 | Imidazole, triazole and tetrazole derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-08-05 | — | — | EP | disclosed |