Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.65 |
| ▸ | FAAH | O00519 | 4/20 | 0.65 |
| ▸ | LTA4H | P09960 | 3/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.62 |
| ▸ | CDK4 | P11802 | 3/20 | 0.55 |
| ▸ | CCND1 | P24385 | 3/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315015 | 0.93 | TRPV1 (0.57) | TRPV1FAAHLTA4HPLA2G2ACDK4 | |
| SCHEMBL7307246 | 0.91 | FAAH (0.56) | TRPV1FAAHLTA4HPLA2G2AMTNR1A | |
| SCHEMBL21564239 | 0.88 | IDO1 (0.60) | TRPV1FAAHLTA4HPLA2G2ACDK4 | |
| SCHEMBL5745010 | 0.85 | MEN1 (0.67) | FAAHCDK4CCND1MTNR1A | |
| SCHEMBL8807970 | 0.84 | HTR7 (0.57) | TRPV1FAAHIDO1MTNR1AMTNR1B | |
| SCHEMBL8613795 | 0.84 | TRPV1 (0.55) | TRPV1FAAHIDO1MTNR1AMTNR1B | |
| SCHEMBL31077788 | 0.84 | TRPV1 (0.70) | TRPV1IDO1 | |
| SCHEMBL798165 | 0.84 | TRPV1 (0.70) | TRPV1IDO1 | |
| SCHEMBL6922503 | 0.84 | CYP1A2 (0.70) | TRPV1FAAHCDK4CCND1IDO1 | |
| SCHEMBL6577939 | 0.83 | FAAH (0.53) | TRPV1FAAHLTA4HPLA2G2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |