Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | SPR | P35270 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807001 | 0.92 | TRPV1 (0.53) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM | |
| SCHEMBL8113405 | 0.90 | TRPV1 (0.53) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM | |
| SCHEMBL8786780 | 0.89 | FAAH (0.52) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM | |
| SCHEMBL8328162 | 0.88 | TRPV1 (0.51) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM | |
| SCHEMBL8613795 | 0.86 | TRPV1 (0.55) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM | |
| SCHEMBL31077788 | 0.86 | TRPV1 (0.70) | TRPV1CYP1A2NOTUMKDM4EALDH1A1 | |
| SCHEMBL798165 | 0.86 | TRPV1 (0.70) | TRPV1CYP1A2NOTUMKDM4EALDH1A1 | |
| SCHEMBL9448768 | 0.85 | TRPM8 (0.54) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM | |
| SCHEMBL7318352 | 0.85 | MTNR1A (0.70) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM | |
| SCHEMBL2544150 | 0.85 | HPGD (0.55) | TRPV1MTNR1AMTNR1BCYP1A2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501568-B1 | Substituted cyclic sulphamide derivatives | MERCK SHARP & DOHME (GB) | 1997-08-20 | — | — | EP | disclosed |
| US-5194440-A | Treatment for migraine; selective agonist | MERCK SHARP & DOHME LTD. (GB) | 1993-03-16 | — | — | US | disclosed |
| EP-0501568-A1 | Substituted cyclic sulphamide derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-09-02 | — | — | EP | disclosed |