Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10994281 | 0.83 | TSHR (0.49) | TSHRMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL11360254 | 0.83 | TSHR (0.49) | TSHRMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL15865532 | 0.77 | KCNA5 (0.45) | TSHRCAPN1MEN1ALDH1A1MAPT | |
| SCHEMBL27389863 | 0.76 | TSHR (0.41) | TSHRCAPN1MEN1APAF1ALDH1A1 | |
| SCHEMBL8784223 | 0.75 | KMT2A (0.50) | TSHRMEN1APAF1ALDH1A1MAPT | |
| SCHEMBL31705786 | 0.75 | HDAC1 (0.48) | TSHRCAPN1MEN1KMT2ANR1H2 | |
| SCHEMBL11990398 | 0.70 | SIGMAR1 (0.47) | TSHRALDH1A1NR1H2 | |
| SCHEMBL9867028 | 0.70 | MTNR1A (0.48) | ALDH1A1KDM4EGAANPSR1MTNR1A | |
| SCHEMBL31374607 | 0.70 | METAP1 (0.55) | MTNR1A | |
| SCHEMBL9938389 | 0.70 | METAP1 (0.55) | MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674625-B1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER (US) | 1997-12-10 | — | — | EP | disclosed |
| CN-1036456-C | Amino-substituted pyrazoles | — | 1997-11-19 | — | — | CN | disclosed |
| US-5668145-A | Amino-substituted pyrazoles having CRF antagonistic activity | PFIZER INC. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0674625-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| CN-1094038-A | The amino pyrazoles that replaces | PFIZER (US) | 1994-10-26 | — | — | CN | disclosed |
| WO-1994013644-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |