Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587856 | 0.77 | CAPN1 (0.39) | KMT2AALDH1A1MAPTAPAF1GAA | |
| SCHEMBL27389863 | 0.75 | TSHR (0.41) | KMT2AMEN1ALDH1A1MAPTAPAF1 | |
| SCHEMBL8784145 | 0.75 | TSHR (0.45) | KMT2AMEN1ALDH1A1MAPTAPAF1 | |
| SCHEMBL23445600 | 0.74 | RNASEH1 (0.49) | KMT2AALDH1A1GAARAB9AHSD17B10 | |
| SCHEMBL14297633 | 0.73 | HPGD (0.39) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL6236827 | 0.73 | HPGD (0.68) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1619264 | 0.73 | HPGD (0.68) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL29760295 | 0.73 | HPGD (0.68) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL28922579 | 0.72 | HTR2C (0.49) | KMT2AACHEKDM4ETSHR | |
| SCHEMBL11246035 | 0.72 | KMT2A (0.44) | KMT2AALDH1A1RAB9AHSD17B10ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674625-B1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5668145-A | Amino-substituted pyrazoles having CRF antagonistic activity | PFIZER INC. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0674625-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013644-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |