Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157232 | 0.87 | ALOX5 (0.56) | MAOBALDH1A1ALOX5CSF1RKDM4E | |
| SCHEMBL8786260 | 0.87 | MAOB (0.54) | MAOBALDH1A1ALOX5CSF1RKDM4E | |
| SCHEMBL8784318 | 0.84 | MAOA (0.48) | ALDH1A1KDM4EMAOAL3MBTL1LMNA | |
| SCHEMBL8785663 | 0.84 | ALOX5 (0.57) | MAOBALDH1A1ALOX5CSF1RKDM4E | |
| SCHEMBL8785092 | 0.82 | CSF1R (0.63) | MAOBALDH1A1ALOX5CSF1RKDM4E | |
| SCHEMBL9153220 | 0.79 | ALOX5 (0.58) | MAOBALDH1A1ALOX5KDM4EGLA | |
| SCHEMBL8784890 | 0.78 | LMNA (0.43) | MAOBALDH1A1KDM4EGLAGAA | |
| SCHEMBL8784023 | 0.78 | TACR1 (0.53) | — | |
| SCHEMBL8786205 | 0.78 | MAOA (0.46) | ALDH1A1KDM4EMAOALMNASMN1; SMN2 | |
| SCHEMBL8402597 | 0.77 | KDM4E (0.55) | ALDH1A1KDM4EGAAMAOAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585913-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5700810-A | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-23 | — | — | US | disclosed |
| US-5482967-A | LOWERING CHOLESTEROL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-01-09 | — | — | US | disclosed |
| EP-0585913-A2 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-09 | — | — | EP | disclosed |