Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784249 | 0.87 | EDNRA (0.47) | EDNRAKDM4EMEN1CYP3A4CYP2C9 | |
| SCHEMBL4765130 | 0.79 | MAPT (0.34) | EDNRAEDNRB | |
| SCHEMBL7840910 | 0.78 | MAPT (0.36) | EDNRA | |
| SCHEMBL4769236 | 0.75 | EDNRA (0.38) | EDNRAEDNRB | |
| SCHEMBL4772914 | 0.74 | EDNRA (0.38) | EDNRA | |
| SCHEMBL6970298 | 0.74 | EDNRA (0.38) | EDNRA | |
| SCHEMBL5528415 | 0.73 | EDNRA (0.35) | EDNRATSHREDNRB | |
| SCHEMBL4767237 | 0.73 | EDNRB (0.39) | EDNRAEDNRB | |
| SCHEMBL5530252 | 0.73 | TP53 (0.32) | EDNRA | |
| SCHEMBL6770127 | 0.72 | EDNRA (0.41) | EDNRAKDM4EMEN1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |