Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788270 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP3A4CYP2C9CYP2C19STAT6 | |
| SCHEMBL8788322 | 0.88 | NPC1 (0.40) | SMN1; SMN2CYP3A4CYP2C9CYP2C19STAT6 | |
| SCHEMBL8787165 | 0.80 | RAB9A (0.63) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL8787834 | 0.79 | TNKS (0.46) | SMN1; SMN2CYP3A4MAPTALDH1A1NPC1 | |
| SCHEMBL8787399 | 0.78 | NPC1 (0.54) | SMN1; SMN2CYP3A4CYP2C9CYP2C19STAT6 | |
| SCHEMBL8787965 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP3A4MAPTALDH1A1NPC1 | |
| SCHEMBL2912377 | 0.76 | ALDH2 (0.66) | SMN1; SMN2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL8788347 | 0.76 | MAOB (0.42) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL8787469 | 0.75 | MAPT (0.50) | SMN1; SMN2CYP3A4MAPTALDH1A1NPC1 | |
| SCHEMBL8787423 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP3A4CYP2C9CYP2C19STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698575-A | Chromone compounds, pharmaceutical compositions containing the same, and use of the same | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0758649-A1 | Chromone derivative, process for preparing same and pharmaceutical composition | Kureha Chemical Industry Co., Ltd. (JP) | 1997-02-19 | — | — | EP | disclosed |