Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449534 | 1.00 | GLA (0.35) | GLABRCA1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL8787746 | 0.86 | KMT2A (0.36) | GLABRCA1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL8787452 | 0.85 | SCN5A (0.33) | GLABRCA1NPC1SCN5ASCN2A | |
| SCHEMBL8787449 | 0.85 | SCN5A (0.33) | GLABRCA1NPC1SCN5ASCN2A | |
| SCHEMBL8787617 | 0.84 | NOS2 (0.33) | GLABRCA1LMNA | |
| SCHEMBL8787613 | 0.84 | NOS2 (0.33) | GLABRCA1LMNA | |
| SCHEMBL8788043 | 0.84 | KMT2A (0.34) | GLABRCA1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL8788038 | 0.84 | KMT2A (0.34) | GLABRCA1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL8788781 | 0.83 | LMNA (0.35) | GLABRCA1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL8787717 | 0.83 | KMT2A (0.36) | NPC1SMN1; SMN2RAB9AHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-B1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5270331-A | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | PFIZER, INC. (US) | 1993-12-14 | — | — | US | disclosed |