Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8787452 | 1.00 | SCN5A (0.33) | SCN5ASCN2AAKR1B10AKR1B1HCAR2 | |
| SCHEMBL8788616 | 0.90 | APP (0.32) | HCAR2 | |
| SCHEMBL8788608 | 0.90 | APP (0.32) | HCAR2 | |
| SCHEMBL8786989 | 0.86 | LMNA (0.32) | NPC1LMNAGLABRCA1 | |
| SCHEMBL8788475 | 0.86 | ALDH1A1 (0.34) | NPC1 | |
| SCHEMBL8788471 | 0.86 | ALDH1A1 (0.34) | NPC1 | |
| SCHEMBL8787652 | 0.85 | GLA (0.35) | SCN5ASCN2AGPR52NPC1CYP1A2 | |
| SCHEMBL9449534 | 0.85 | GLA (0.35) | SCN5ASCN2AGPR52NPC1CYP1A2 | |
| SCHEMBL8787335 | 0.83 | MAPT (0.33) | NPC1LMNA | |
| SCHEMBL8787340 | 0.83 | MAPT (0.33) | NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-B1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5270331-A | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | PFIZER, INC. (US) | 1993-12-14 | — | — | US | disclosed |