Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.69 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.69 |
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.60 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | KDM5C | P41229 | 4/20 | 0.60 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.59 |
| ▸ | KDM6B | O15054 | 2/20 | 0.55 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5875196 | 1.00 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL9472424 | 0.96 | EGLN1 (0.64) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Adipic Acid SCHEMBL5874433 | 0.86 | LMNA (0.73) | LMNASLC22A6OR51E2TSHRNFKB1 | |
| Adipic Acid SCHEMBL5874442 | 0.86 | LMNA (0.73) | LMNASLC22A6OR51E2TSHRNFKB1 | |
| Glutarate SCHEMBL5874409 | 0.86 | SLC22A6 (0.73) | LMNASLC22A6OR51E2TSHRNFKB1 | |
| Glutarate SCHEMBL5874404 | 0.86 | SLC22A6 (0.73) | LMNASLC22A6OR51E2TSHRNFKB1 | |
| Succinic Acid SCHEMBL3628497 | 0.84 | EGLN1 (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL28297794 | 0.84 | LMNA (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL27584447 | 0.84 | EGLN1 (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL30575212 | 0.84 | EGLN1 (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113699618-A | Method for preparing high-resilience spandex fiber by utilizing spandex waste silk | 诸暨华海氨纶有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-108602772-A | Novel crystal form of 1- (5- (2, 4-difluorophenyl) -1- ((3-fluorophenyl) sulfonyl) -4-methoxy-1H-pyrrole-3-yl) -N-methylmelamine salt | 株式会社大熊制药 | 2018-09-28 | — | — | CN | claimed |
| US-20230293404-A1 | Compositions Comprising Natural Polymers and One or More (Bio)-Alkanediols | SYMRISE AG (DE) | 2023-09-21 | — | — | US | disclosed |
| US-20230293406-A1 | Compositions Comprising (Bio)-Alkanediols and Cooling Agents | SYMRISE AG (DE) | 2023-09-21 | — | — | US | disclosed |
| CN-114616225-A | Treprostinil prodrugs | 联合治疗公司 | 2022-06-10 | — | — | CN | disclosed |
| EP-3097905-B1 | COSMETIC COMPOSITIONS | SYMRISE AG (DE) | 2020-11-04 | — | — | EP | disclosed |
| CN-108602771-A | The new acid-addition salts of 1- (5- (2,4 difluorobenzene base) -1- ((3- fluorophenyls) sulfonyl) -4- methoxyl group -1H- pyrroles -3- bases)-N- methyl methylamines | 株式会社大熊制药 | 2018-09-28 | — | — | CN | disclosed |
| CN-108602772-A | Novel crystal form of 1- (5- (2, 4-difluorophenyl) -1- ((3-fluorophenyl) sulfonyl) -4-methoxy-1H-pyrrole-3-yl) -N-methylmelamine salt | 株式会社大熊制药 | 2018-09-28 | — | — | CN | disclosed |
| EP-3097905-A1 | COSMETIC COMPOSITIONS | Symrise AG (DE) | 2016-11-30 | — | — | EP | disclosed |
| CN-104938523-A | Plant dormancy agent and dormancy method of transplanted trees | ZHEJIANG YUANCHENG LANDSCAPE GROUP CO LTD | 2015-09-30 | — | — | CN | disclosed |
| WO-2006129190-A1 | PROCESS FOR THE PREPARATION OF ALMOTRIPTAN | GLENMARK PHARMACEUTICALS LIMITED (US) | 2006-12-07 | — | — | WO | disclosed |
| US-4550205-A | CONTROLLING WEEDS; LEAF-DESSICATION; DEFOLIATION | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1985-10-29 | — | — | US | disclosed |
| EP-0080746-B1 | NEW DIPHENYL ETHERS HAVING HERBICIDAL ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1985-08-21 | — | — | EP | disclosed |
| US-4163658-A | 1,2,3-Thiadiazole-5-yl-urea derivatives, process for making the same and plant retardation and defoliation composition containing same | SCHERING AKTIENGESELLSCHAFT (DE) | 1979-08-07 | — | — | US | disclosed |
| US-4139367-A | QUATERNARY AMMONIUM COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4130414-A | 1,2,3-Thiadiazole-5-yl-urea derivatives, process for making the same and plant retardation and defoliation composition containing same | SCHERING AG (DE) | 1978-12-19 | — | — | US | disclosed |
| US-4098598-A | PLANT GROWTH REGULATORS | HOFFMANN-LA ROCHE INC. (US) | 1978-07-04 | — | — | US | disclosed |
| US-4094664-A | 6-AMINO-O-TOLUIC ACID, HERBICIDES | HOFFMANN-LA ROCHE INC. (US) | 1978-06-13 | — | — | US | disclosed |
| US-4028089-A | BENZOXAZOLINYLIDENE-MALONITRILE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1977-06-07 | — | — | US | disclosed |
| US-4014678-A | 1-(3,7-Dimethyloctyl)-1(2-propenyl)-and 1(2-propynyl)-piperidinium bromides as plant growth regulants | HOFFMANN-LA ROCHE INC. (US) | 1977-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230293406-A1 | Compositions Comprising (Bio)-Alkanediols and Cooling Agents | OR51E2, MAL2, ADH1C | EGLN1 2677/4885LMNA 4046/4885ALKBH5 32/4885 |
| US-20230293404-A1 | Compositions Comprising Natural Polymers and One or More (Bio)-Alkanediols | ACMSD, CUTA, DDC | EGLN1 1150/4885LMNA 3696/4885ALKBH5 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.