Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 7/20 | 0.40 |
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788085 | 0.89 | DRD2 (0.41) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL1545159 | 0.80 | HTR1D (0.52) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8788384 | 0.79 | CCR3 (0.44) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8788032 | 0.78 | DRD2 (0.47) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL8787809 | 0.76 | HTR1A (0.41) | DRD2HTR2AHTR7ACHE | |
| SCHEMBL8789213 | 0.76 | DRD2 (0.43) | DRD2SLC6A4HTR2AHTR7ACHE | |
| SCHEMBL1545719 | 0.74 | DRD2 (0.74) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| Hydrochloric Acid SCHEMBL9231660 | 0.73 | DRD2 (0.45) | DRD2SLC6A4HTR2AHTR7KCNH2 | |
| SCHEMBL7769075 | 0.72 | HTR1A (0.49) | DRD2SLC6A4HTR2AKCNH2ACHE | |
| SCHEMBL1545221 | 0.70 | HTR1D (0.51) | DRD2SLC6A4HTR2AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730452-A4 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST ROUSSEL PHARMA (US) | 1997-03-19 | — | — | EP | claimed |
| EP-0730452-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST MARION ROUSSEL, Inc. (US) | 1996-09-11 | — | — | EP | claimed |