Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.35 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8788526 | 1.00 | KMT2A (0.42) | KMT2AMEN1DRD4ALDH1A1HTT | |
| Fumaric Acid SCHEMBL8643287 | 0.94 | ALDH1A1 (0.39) | KMT2AMEN1ALDH1A1MAPT | |
| Fumaric Acid SCHEMBL8643277 | 0.94 | ALDH1A1 (0.39) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8787526 | 0.93 | ALDH1A1 (0.42) | KMT2AMEN1DRD4ALDH1A1HTT | |
| Fumaric Acid SCHEMBL8646610 | 0.86 | DRD2 (0.43) | KMT2AMEN1DRD4ALDH1A1HTT | |
| SCHEMBL8644873 | 0.78 | DRD2 (0.48) | KMT2AMEN1DRD4ALDH1A1HTT | |
| SCHEMBL8643747 | 0.77 | MTR (0.44) | KMT2AMEN1ALDH1A1DRD2DRD3 | |
| Fumaric Acid SCHEMBL8644275 | 0.77 | UTS2R (0.46) | KMT2AMEN1DRD4HTR2AHTR7 | |
| SCHEMBL8788519 | 0.76 | ALDH1A1 (0.43) | KMT2AMEN1DRD4ALDH1A1HTT | |
| SCHEMBL8649403 | 0.76 | MTR (0.43) | KMT2AMEN1ALDH1A1HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753514-A1 | ALKYLENEDIAMINE DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1997-01-15 | — | — | EP | disclosed |