SCHEMBL8788600

SCHEMBL8788600

O=C1CN(SS(=O)(=O)C2Cc3ccccc3C2)C(=O)N1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 2/20 0.33
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
BRD4 O60885 2/20 0.33
CREBBP Q92793 2/20 0.33
POLB P06746 2/20 0.32
APOBEC3A P31941 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ALDH1A1 P00352 2/20 0.32
MAPT P10636 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
PARP1 P09874 1/20 0.31
MMP8 P22894 4/20 0.31
MMP3 P08254 2/20 0.31
AHR P35869 1/20 0.31
PDK2 Q15119 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8789424 0.75 ALDH1A1 (0.41) CRBNPDE3BPDE3ABRD4CREBBP
SCHEMBL8788986 0.75 CRBN (0.31) CRBN
SCHEMBL8790932 0.75 CRBN (0.31) CRBN
SCHEMBL8788472 0.75 CRBN (0.31) CRBN
SCHEMBL8788603 0.69 ALDH1A1 (0.38) CRBNPDE3BPDE3ABRD4CREBBP
Benzene SCHEMBL27623239 0.67 MAPT (0.46) CRBNPDE3BPDE3APOLBTDP1
SCHEMBL62940 0.67 MAPT (0.46) CRBNPDE3BPDE3APOLBTDP1
SCHEMBL27404604 0.63 PTGS2 (0.39) CRBNBRD4ALDH1A1MAPT
SCHEMBL9864475 0.62 MAPT (0.38) CRBNPDE3BPDE3APOLBTDP1
SCHEMBL22498758 0.60 CRBN (0.35) CRBNPDE3BPDE3APOLBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788796-A1 URICOSURIC AGENT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1997-08-13 EP disclosed