Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7692326 | 0.97 | ESR1 (0.43) | ESR1ESR2MAPK1KDM4EALDH1A1 | |
| SCHEMBL8789363 | 0.85 | MAPK1 (0.36) | ESR1ESR2MAPK1KDM4EALDH1A1 | |
| SCHEMBL8790299 | 0.81 | CCNB2 (0.41) | ESR1ESR2MAPK1KDM4EALDH1A1 | |
| SCHEMBL9356958 | 0.80 | NR1I2 (0.40) | MAPK1CCNB2CDK1CCNB1GSK3A | |
| SCHEMBL8792445 | 0.80 | CCNB2 (0.38) | ESR1MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL8789330 | 0.80 | CCNB2 (0.40) | ESR1MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL8789465 | 0.79 | CCNB2 (0.42) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL9027686 | 0.79 | ALDH1A1 (0.39) | MAPK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9027574 | 0.76 | DRD2 (0.39) | MAPK1CCNB2CDK1CCNB1GSK3A | |
| SCHEMBL9028366 | 0.75 | CCNB2 (0.38) | MAPK1CCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772591-A1 | 2-PHENYL INDOLES AS ANTI-OESTROGEN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003375-A1 | 2-PHENYL INDOLES AS ANTI-OESTROGEN DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-02-08 | — | — | WO | disclosed |