Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | DRD3 | P35462 | 7/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9356958 | 0.82 | NR1I2 (0.40) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL9028683 | 0.81 | CCNB2 (0.40) | DRD2DRD3CCNB2CDK1CCNB1 | |
| SCHEMBL8790299 | 0.77 | CCNB2 (0.41) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL8790260 | 0.76 | ESR1 (0.39) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL8789330 | 0.76 | CCNB2 (0.40) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL8792445 | 0.76 | CCNB2 (0.38) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL7692326 | 0.76 | ESR1 (0.43) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL8789363 | 0.75 | MAPK1 (0.36) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL9027686 | 0.75 | ALDH1A1 (0.39) | CCNB2CCNE2INSRCDK1CFTR | |
| SCHEMBL9027633 | 0.73 | ESR1 (0.43) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736008-A1 | INDOLE DERIVATIVES AS ANTI-ESTROGENS | KARO BIO AB (SE) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017383-A1 | INDOLE DERIVATIVES AS ANTI-ESTROGENS | KARO BIO AB (SE) | 1995-06-29 | — | — | WO | disclosed |