Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.66 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | PPIB | P23284 | 1/20 | 0.46 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790187 | 0.86 | LTB4R (0.59) | ALOX5AOC3PPIBALDH1A1HTT | |
| SCHEMBL8790338 | 0.85 | CDK8 (0.63) | AOC3ALDH1A1HTTLTB4RLTB4R2 | |
| SCHEMBL8790741 | 0.84 | MAPK1 (0.56) | ALOX5AOC3PPIBALDH1A1HTT | |
| SCHEMBL8789569 | 0.83 | ALOX5 (0.60) | ALOX5BCHEACHEALDH1A1 | |
| SCHEMBL8790580 | 0.81 | ALDH1A1 (0.61) | ALOX5BCHEACHEPPIBF2RL1 | |
| SCHEMBL10691859 | 0.80 | ALOX5 (1.00) | ALOX5BCHEACHEF2RL1ALDH1A1 | |
| SCHEMBL31329297 | 0.80 | ALOX5 (0.82) | ALOX5BCHEACHEF2RL1ALDH1A1 | |
| SCHEMBL13792415 | 0.77 | ALOX5 (0.77) | ALOX5BCHEACHEF2RL1ALDH1A1 | |
| SCHEMBL9023046 | 0.77 | ALOX5 (0.55) | ALOX5BCHEACHEAOC3F2RL1 | |
| SCHEMBL31329298 | 0.77 | ALOX5 (0.68) | ALOX5BCHEACHEALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |