Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791157 | 0.85 | PKM (0.36) | ALDH1A1HPGDPKM | |
| SCHEMBL8791363 | 0.81 | NQO2 (0.42) | ALDH1A1HPGDKDM4EHSD17B2MGLL | |
| SCHEMBL8789847 | 0.81 | DAO (0.33) | ALDH1A1HPGDKDM4EMGLLMEN1 | |
| SCHEMBL8790808 | 0.78 | KDM4E (0.38) | ALDH1A1HPGDL3MBTL1KDM4EMGLL | |
| SCHEMBL8790845 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDKMT2AHSD11B1 | |
| SCHEMBL8791239 | 0.76 | POLB (0.38) | ALDH1A1KDM4EMGLLPOLBKMT2A | |
| SCHEMBL8791140 | 0.75 | ALDH1A1 (0.35) | ALDH1A1HPGDL3MBTL1PKMMGLL | |
| SCHEMBL8790916 | 0.75 | KMT2A (0.38) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL8791435 | 0.74 | RPS6KB2 (0.30) | — | |
| SCHEMBL9568787 | 0.73 | HSD11B1 (0.46) | ALDH1A1PKMMGLLPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |