Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790916 | 0.87 | KMT2A (0.38) | GRIN1GRIN2BKDM4EALDH1A1LMNA | |
| SCHEMBL8791435 | 0.86 | RPS6KB2 (0.30) | RPS6KB2 | |
| SCHEMBL8791911 | 0.83 | MAPT (0.33) | RPS6KB2KDM4EALDH1A1 | |
| SCHEMBL8791239 | 0.83 | POLB (0.38) | KDM4EALDH1A1LMNA | |
| SCHEMBL8789847 | 0.83 | DAO (0.33) | KDM4EALDH1A1HPGDHSD11B1 | |
| SCHEMBL8790808 | 0.80 | KDM4E (0.38) | KDM4EALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL8791363 | 0.78 | NQO2 (0.42) | KDM4EALDH1A1HPGDHSD11B1 | |
| SCHEMBL9845581 | 0.78 | ALDH1A1 (0.47) | DPP4GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL8791157 | 0.77 | PKM (0.36) | ALDH1A1HPGD | |
| SCHEMBL8973496 | 0.73 | POLB (0.32) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |